0000950170-24-095760 | 10-Q | XBRL Viewer

Stockholders' Equity (Tables)

6 Months Ended

Jun. 30, 2024

Class of Stock Disclosures [Abstract]

Schedule of Common Stock Shares Reserved for the Potential Conversion of Outstanding Preferred Stock and Exercise of Stock Options

As of June 30, 2024 and December 31, 2023, the Company had reserved the following shares of common stock for the potential exercise of stock options, potential exercise of pre-funded warrants, vesting of restricted stock units, as well as the remaining shares available for issuance under the 2022 Stock Option Incentive Plan (the “2022 Plan”), the 2022 Employee Stock Purchase Plan (the “2022 ESPP”), and the 2023 Inducement Plan (the “Inducement Plan”):


	June 30, 2024		December 31, 2023
Options to purchase common stock		4,356,771		3,117,042
Pre-funded warrants to purchase common stock		7,060,000		—
Unvested restricted stock units		1,472,741		1,759,918
Remaining shares reserved for future issuance		2,297,940		2,107,745
Total		15,187,452		6,984,705

Summary of Significant Accounting Policies	6 Months Ended
Jun. 30, 2024
Accounting Policies [Abstract]
Summary of Significant Accounting Policies	2. Summary of Significant Accounting Policies The significant accounting policies and estimates used in the preparation of the accompanying unaudited condensed consolidated financial statements are described in the Company’s audited consolidated financial statements for the year ended December 31, 2023 included in the Company’s Annual Report on Form 10-K filed with the SEC on March 28, 2024. There have been no material changes in the Company’s significant accounting policies during the six months ended June 30, 2024, except as noted below. Pre-Funded Warrants Warrants are accounted for based on the specific terms of the warrant agreements. The Company's pre-funded warrants are indexed to the Company's common stock and meet the criteria to be classified as equity. Proceeds from the issuance of pre-funded warrants are recorded within additional paid-in capital and are not subject to remeasurement. Refer to Note 8 and Note 10 for further information regarding pre-funded warrants issued by the Company. Unaudited Interim Financial Information The accompanying unaudited condensed consolidated financial statements have been prepared in conformity with accounting principles generally accepted in the United States of America (“U.S. GAAP”) and include the operations of Acrivon Therapeutics, Inc. and its wholly-owned subsidiaries. All intercompany accounts, transactions and balances have been eliminated in consolidation. The accompanying condensed consolidated interim financial statements are unaudited but have been prepared on the same basis as the audited annual financial statements and, in the opinion of management, reflect all adjustments, which include only normal recurring adjustments necessary for the fair statement of the Company’s financial position as of June 30, 2024 and the results of its operations for the three and six months ended June 30, 2024 and 2023 and its cash flows for the six months ended June 30, 2024 and 2023. The consolidated balance sheet as of December 31, 2023 was derived from audited annual financial statements but does not include all disclosures required by U.S. GAAP. The results for the three and six months ended June 30, 2024 are not necessarily indicative of results to be expected for the full year or for any other subsequent interim period. Recently Adopted Accounting Pronouncements ASU 2023-07, Segment Reporting (Topic 280) In November 2023, the FASB issued ASU 2023-07, Segment Reporting (Topic 280): Improvements to Reportable Segment Disclosures, which requires public entities to disclose information about their reportable segments’ significant expenses on an interim and annual basis. All disclosure requirements under ASU 2023-07 are also required for public entities with a single reportable segment. The ASU is effective for annual periods beginning after December 15, 2023 and for interim periods within fiscal years beginning after December 15, 2024. The Company adopted this accounting standard as of January 1, 2024, with no material impact on its condensed consolidated financial statements and related disclosures.

Summary of Significant Accounting Policies

6 Months Ended

Jun. 30, 2024

Accounting Policies [Abstract]

Summary of Significant Accounting Policies

2. Summary of Significant Accounting Policies

The significant accounting policies and estimates used in the preparation of the accompanying unaudited condensed consolidated financial statements are described in the Company’s audited consolidated financial statements for the year ended December 31, 2023 included in the Company’s Annual Report on Form 10-K filed with the SEC on March 28, 2024. There have been no material changes in the Company’s significant accounting policies during the six months ended June 30, 2024, except as noted below.

Pre-Funded Warrants

Warrants are accounted for based on the specific terms of the warrant agreements. The Company's pre-funded warrants are indexed to the Company's common stock and meet the criteria to be classified as equity. Proceeds from the issuance of pre-funded warrants are recorded within additional paid-in capital and are not subject to remeasurement. Refer to Note 8 and Note 10 for further information regarding pre-funded warrants issued by the Company.

Unaudited Interim Financial Information

The accompanying unaudited condensed consolidated financial statements have been prepared in conformity with accounting principles generally accepted in the United States of America (“U.S. GAAP”) and include the operations of Acrivon Therapeutics, Inc. and its wholly-owned subsidiaries. All intercompany accounts, transactions and balances have been eliminated in consolidation.

The accompanying condensed consolidated interim financial statements are unaudited but have been prepared on the same basis as the audited annual financial statements and, in the opinion of management, reflect all adjustments, which include only normal recurring adjustments necessary for the fair statement of the Company’s financial position as of June 30, 2024 and the results of its operations for the three and six months ended June 30, 2024 and 2023 and its cash flows for the six months ended June 30, 2024 and 2023. The consolidated balance sheet as of December 31, 2023 was derived from audited annual financial statements but does not include all disclosures required by U.S. GAAP.

The results for the three and six months ended June 30, 2024 are not necessarily indicative of results to be expected for the full year or for any other subsequent interim period.

Recently Adopted Accounting Pronouncements

ASU 2023-07, Segment Reporting (Topic 280)

In November 2023, the FASB issued ASU 2023-07, Segment Reporting (Topic 280): Improvements to Reportable Segment Disclosures, which requires public entities to disclose information about their reportable segments’ significant expenses on an interim and annual basis. All disclosure requirements under ASU 2023-07 are also required for public entities with a single reportable segment. The ASU is effective for annual periods beginning after December 15, 2023 and for interim periods within fiscal years beginning after December 15, 2024. The Company adopted this accounting standard as of January 1, 2024, with no material impact on its condensed consolidated financial statements and related disclosures.

Document and Entity Information - shares	6 Months Ended
Document and Entity Information - shares	Jun. 30, 2024	Aug. 08, 2024
Cover [Abstract]
Document Type	10-Q
Amendment Flag	false
Document Period End Date	Jun. 30, 2024
Document Fiscal Year Focus	2024
Document Fiscal Period Focus	Q2
Trading Symbol	ACRV
Entity Registrant Name	Acrivon Therapeutics, Inc.
Entity Central Index Key	0001781174
Current Fiscal Year End Date	--12-31
Entity Filer Category	Non-accelerated Filer
Entity Small Business	true
Entity Emerging Growth Company	true
Entity Ex Transition Period	false
Entity Common Stock, Shares Outstanding		30,972,163
Entity Current Reporting Status	Yes
Entity Shell Company	false
Entity File Number	001-41551
Entity Tax Identification Number	82-5125532
Entity Address, Address Line One	480 Arsenal Way
Entity Address, Address Line Two	Suite 100
Entity Address, City or Town	Watertown
Entity Address, State or Province	MA
Entity Address, Postal Zip Code	02472
City Area Code	617
Local Phone Number	207-8979
Entity Incorporation, State or Country Code	DE
Entity Interactive Data Current	Yes
Title of 12(b) Security	Common Stock, par value $0.001 per share
Security Exchange Name	NASDAQ
Document Quarterly Report	true
Document Transition Report	false

Leases - Schedule of Components of Lease Cost (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023
Leases [Abstract]
Operating lease cost	$ 317	$ 286	$ 634	$ 572
Variable lease cost	170	152	299	248
Sublease income				(134)
Total lease cost	$ 487	$ 438	$ 933	$ 686

Leases - Summary of Presentation of Operating Leases on Condensed Consolidated Balance Sheet (Details) - USD ($) $ in Thousands	Jun. 30, 2024	Dec. 31, 2023
Assets
Operating lease right-of-use assets	$ 3,976	$ 4,429
Current liabilities:
Operating lease liabilities, current	978	877
Noncurrent:
Operating lease liabilities, long-term	3,243	3,767
Total lease liabilities	$ 4,221	$ 4,644

Fair Value Measurement

6 Months Ended

Jun. 30, 2024

Fair Value Disclosures [Abstract]

Fair Value Measurement

4. Fair Value Measurement

The following tables present information about the Company’s financial assets measured at fair value on a recurring basis and indicate the level of the fair value hierarchy to determine such fair value (in thousands):


			Fair Value Measurements at June 30, 2024 Using:
Assets:	Total		Level 1		Level 2		Level 3
Cash equivalents:
Money market funds	$	36,885	$	36,885	$	—	$	—
Short-term investments:
U.S. Treasury securities		134,531		134,531		—		—
Long-term investments:
U.S. Treasury securities		39,895		39,895		—		—
Total assets	$	211,311	$	211,311	$	—	$	—


			Fair Value Measurements at December 31, 2023 Using:
Assets:	Total		Level 1		Level 2		Level 3
Cash equivalents:
Money market funds	$	31,191	$	31,191	$	—	$	—
Short-term investments:
U.S. Treasury securities		41,473		41,473		—		—
U.S. government-sponsored enterprise securities		49,970		—		49,970		—
Total assets	$	122,634	$	72,664	$	49,970	$	—

The Company classifies its money market funds and U.S. Treasury securities as Level 1 assets under the fair value hierarchy as these assets have been valued using quoted market prices in active markets without any valuation adjustment. The Company classifies its U.S. government-sponsored enterprise securities as Level 2 assets under the fair value hierarchy as these assets have been valued using information obtained through a third-party pricing service as of the balance sheet date, using observable market inputs that may include trade information, broker or dealer quotes, bids, offers, or a combination of these data sources.

During the six months ended June 30, 2024 and the year ended December 31, 2023, there were no transfers between levels. The Company uses the carrying amounts of its restricted cash, prepaid expenses and other current assets, accounts payable, and accrued expenses and other current liabilities to approximate their fair values due to the short-term nature of these amounts.

- Definition

The entire disclosure for the fair value of financial instruments (as defined), including financial assets and financial liabilities (collectively, as defined), and the measurements of those instruments as well as disclosures related to the fair value of non-financial assets and liabilities. Such disclosures about the financial instruments, assets, and liabilities would include: (1) the fair value of the required items together with their carrying amounts (as appropriate); (2) for items for which it is not practicable to estimate fair value, disclosure would include: (a) information pertinent to estimating fair value (including, carrying amount, effective interest rate, and maturity, and (b) the reasons why it is not practicable to estimate fair value; (3) significant concentrations of credit risk including: (a) information about the activity, region, or economic characteristics identifying a concentration, (b) the maximum amount of loss the entity is exposed to based on the gross fair value of the related item, (c) policy for requiring collateral or other security and information as to accessing such collateral or security, and (d) the nature and brief description of such collateral or security; (4) quantitative information about market risks and how such risks are managed; (5) for items measured on both a recurring and nonrecurring basis information regarding the inputs used to develop the fair value measurement; and (6) for items presented in the financial statement for which fair value measurement is elected: (a) information necessary to understand the reasons for the election, (b) discussion of the effect of fair value changes on earnings, (c) a description of [similar groups] items for which the election is made and the relation thereof to the balance sheet, the aggregate carrying value of items included in the balance sheet that are not eligible for the election; (7) all other required (as defined) and desired information.

+ References

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+ Details

Leases

6 Months Ended

Jun. 30, 2024

Leases [Abstract]

Leases

7. Leases

In December 2020, the Company entered into a lease agreement for laboratory and office space located at 480 Arsenal Way, Watertown, Massachusetts (the “Arsenal Way Lease”). The lease commenced in April 2021, with a term of seven years and an option to extend the term for an additional five years. The Company delivered a letter of credit of $0.3 million to the landlord, which is included in restricted cash in the accompanying condensed consolidated balance sheets. Under the terms of the lease, the base rent is $1.0 million, subject to a 3% annual rent increase, plus an allocation of operating expenses and taxes. In May 2021, the Company subleased a portion of its Arsenal Way Lease to a subtenant. The sublease term expired in March 2023.

In August 2023, the Company entered into an operating lease agreement, denominated in Swedish Krona, for office and laboratory space located in Lund, Sweden. The term of the lease commenced in December 2023. The lease has an initial term of three years, with an option to extend the term for an additional three years.

The following table summarizes the presentation of the Company’s operating leases on its condensed consolidated balance sheets (in thousands):


Leases	Balance sheet classification	June 30, 2024		December 31, 2023
Assets:
Operating lease assets	Operating lease right-of-use assets	$	3,976	$	4,429
Total lease assets		$	3,976	$	4,429
Liabilities:
Current:
Operating lease liabilities	Operating lease liability, current	$	978	$	877
Noncurrent:
Operating lease liabilities	Operating lease liability, long-term		3,243		3,767
Total lease liabilities		$	4,221	$	4,644

The components of lease cost under ASC 842 included within research and development expenses and general and administrative expenses in the Company’s condensed consolidated statements of operations and comprehensive loss were as follows (in thousands):


	Three Months Ended June 30,				Six Months Ended June 30,
Lease cost	2024		2023		2024		2023
Operating lease cost	$	317	$	286	$	634	$	572
Variable lease cost		170		152		299		248
Sublease income		—		—		—		(134	)
Total lease cost	$	487	$	438	$	933	$	686

As of June 30, 2024 and December 31, 2023, the weighted-average remaining lease term for operating leases was 3.7 years and 4.2 years, respectively, and the weighted-average discount rate was 8.29% and 8.30%, respectively. Cash paid for amounts included in the measurement of lease liabilities was $0.6 million and $0.5 million for the six months ended June 30, 2024 and 2023, respectively.

Future minimum annual lease commitments under the Company’s non-cancelable operating leases as of June 30, 2024 were as follows (in thousands):


Fiscal Year	Amount
2024 (remaining 6 months)	$	633
2025		1,306
2026		1,340
2027		1,200
2028		404
Thereafter		—
Total lease payments		4,883
Less: interest		(662	)
Present value of operating lease liabilities	$	4,221

Nature of the Business

6 Months Ended

Jun. 30, 2024

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Nature of the Business

1. Nature of the Business

Acrivon Therapeutics, Inc., (the “Company”) is a clinical stage biopharmaceutical company developing precision medicines that the Company matches to patients whose tumors are predicted to be sensitive to each specific medicine by utilizing its proteomics-based patient responder identification platform. Acrivon is currently advancing its lead candidate, ACR-368, (also known as prexasertib), a selective small molecule inhibitor targeting CHK1 and CHK2 in a potentially registrational Phase 2 trial across multiple tumor types. The Company has received Fast Track designation from the Food and Drug Administration (“FDA”) for the investigation of ACR-368 as monotherapy based on OncoSignature-predicted sensitivity in patients with platinum-resistant ovarian or endometrial cancer. Acrivon’s ACR-368 OncoSignature test, which has not yet obtained regulatory approval, has been extensively evaluated in preclinical studies, including in two separate, blinded, prospectively-designed studies on pretreatment tumor biopsies collected from past third-party Phase 2 trials in patients with ovarian cancer treated with ACR-368. The FDA has granted Breakthrough Device designation for the ACR-368 OncoSignature assay for the identification of ovarian cancer patients who may benefit from ACR-368 treatment. In April 2024, the Company reported initial positive clinical data from its ongoing registrational-intent Phase 2b trial of ACR-368 for patients with locally advanced or metastatic, recurrent platinum-resistant ovarian cancer or endometrial adenocarcinoma (data cut as of April 1, 2024), including a confirmed objective response rate (per RECIST 1.1) of 50% in the prospective cohort of OncoSignature-positive patients who were efficacy-evaluable. In addition to ACR-368, Acrivon is also leveraging its proprietary AP3 precision medicine platform for developing its co-crystallography-driven, internally-discovered preclinical stage pipeline programs. These include ACR-2316, a potent, selective WEE1/PKMYT1 inhibitor designed for superior single-agent activity as demonstrated in preclinical studies against benchmark inhibitors, and a cell cycle program with an undisclosed target. The Company reported in April 2024 that it is on track for Investigational New Drug filing in the third quarter of 2024, one quarter ahead of previously disclosed timelines.

The Company was incorporated in March 2018 under the laws of the state of Delaware, and its principal offices are in Watertown, Massachusetts. Also in March 2018, the Company formed Acrivon AB, a wholly-owned subsidiary of the Company, established in Lund, Sweden. In December 2021, the Company formed Acrivon Securities Corporation, a wholly-owned subsidiary, established in Massachusetts.

Liquidity

As an emerging growth entity, the Company has devoted substantially all of its resources since inception to organizing and staffing the Company, business planning, raising capital, establishing its intellectual property portfolio, acquiring or discovering drug candidates, research and development activities for the Company's lead candidate ACR-368, for the Company's internally discovered development candidate ACR-2316, and other compounds, establishing arrangements with third parties for the manufacture of its drug candidates and component materials, and providing general and administrative support for these operations. As a result, the Company has incurred significant operating losses and negative cash flows from operations since its inception and anticipates such losses and negative cash flows will continue for the foreseeable future.

The Company has incurred recurring losses since its inception, including net losses of $35.3 million and $26.7 million for the six months ended June 30, 2024 and 2023, respectively. As of June 30, 2024 and December 31, 2023 the Company had an accumulated deficit of $151.7 million and $116.4 million, respectively. To date the Company has not generated any revenues and expects to continue generating operating losses for the foreseeable future as it continues to expand its research and development efforts.

Since its inception, the Company has funded its operations primarily with proceeds from the sales of shares of its convertible preferred stock, the issuance of convertible notes, and an initial public offering (“IPO”) and concurrent private placement. Upon the closing of the Company’s IPO on November 17, 2022, only common stock remains issued and outstanding. On April 8, 2024, the Company entered into a Private Investment in Public Equity (“PIPE”) securities purchase agreement (the “PIPE Purchase Agreement”) for a private placement with certain institutional and accredited investors (the “April 2024 Private Placement”). Pursuant to the PIPE Purchase Agreement, the Company agreed to issue and sell to the PIPE investors an aggregate of (i) 8,235,000 shares of the Company’s common stock at a purchase price of $8.50 per share, and (ii) pre-funded warrants (“Pre-Funded Warrants”) to purchase up to an aggregate of 7,060,000 shares of the Company’s common stock at a purchase price of $8.499 per Pre-Funded Warrant, which represents the per share purchase price of the Company’s common stock less the $0.001 per share exercise price for each Pre-Funded Warrant. The Pre-Funded Warrants are exercisable at any time after the date of issuance and do not expire. The April 2024 Private Placement closed on April 11, 2024, for aggregate net proceeds of $123.8 million, after deducting fees and expenses of $6.2 million. The April 2024 Private Placement is further described in Note 8.

The Company expects that its existing cash, cash equivalents and investments of $220.4 million as of June 30, 2024, will be sufficient to fund its operating expenses and capital expenditure requirements into the second half of 2026, which is at least 12 months from the date these condensed consolidated financial statements were issued.

The Company will need additional funding to support its planned operating activities. There can be no assurances, however, that the current operating plan will be achieved or that additional funding will be available on terms acceptable to the Company, or at all, considering the current interest rate environment. If the Company is unable to obtain sufficient funding, it could be required to delay its development efforts, limit activities and reduce research and development costs, which could adversely affect its business prospects.

ATM Program

On December 1, 2023, the Company filed a registration statement on Form S-3 (the “Registration Statement”) with the U.S. Securities and Exchange Commission (the “SEC”), which was declared effective on December 15, 2023, which registered the offering, issuance, and sale of up to a maximum aggregate offering price of $300.0 million of common stock, preferred stock, debt securities, warrants and/or units of any combination thereof. The Company simultaneously entered into a sales agreement with Cowen and Company, LLC, as sales agent, to provide for the issuance and sale by the Company of up to $100.0 million of common stock from time to time in “at-the-market” offerings under the Registration Statement and related prospectus (“ATM Program”). As of June 30, 2024, no sales had been made pursuant to the ATM Program.

Investments (Tables)

6 Months Ended

Jun. 30, 2024

Investments, Debt and Equity Securities [Abstract]

Summary of Amortized Cost and Estimated Fair Value of Investments

The following table summarizes the amortized cost and estimated fair value of the Company's U.S. Treasury securities and U.S. government-sponsored enterprise securities, which are considered to be available-for-sale investments and were included in short-term and long-term investments as of June 30, 2024 and in short-term investments as of December 31, 2023 (in thousands):


	June 30, 2024
Short-term investments:	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Fair Value
U.S. Treasury securities	$	134,588	$	3	$	(60	)	$	134,531
Long-term investments:
U.S. Treasury securities		39,857		38		—			39,895
	$	174,445	$	41	$	(60	)	$	174,426


	December 31, 2023
	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Fair Value
Short-term investments:
U.S. Treasury securities	$	41,470	$	22	$	(19	)	$	41,473
U.S. government-sponsored enterprise securities		50,056		—		(86	)		49,970
	$	91,526	$	22	$	(105	)	$	91,443

Accrued Expenses and Other Current Liabilities - Summary of Accrued Expenses and Other Current Liabilities (Details) - USD ($) $ in Thousands	Jun. 30, 2024	Dec. 31, 2023
Payables and Accruals [Abstract]
Accrued research and development expenses	$ 5,069	$ 2,661
Accrued compensation and benefits	2,947	3,860
Accrued legal, accounting and other professional fees	600	667
Accrued offering costs	283
Accrued other	146	190
Total accrued expenses and other current liabilities	$ 9,045	$ 7,378

CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (UNAUDITED) - USD ($) $ in Thousands	Total	Private Placement	Pre-Funded Warrants Private Placement	Common Stock	Common Stock Private Placement	Additional Paid-In Capital	Additional Paid-In Capital Private Placement	Additional Paid-In Capital Pre-Funded Warrants Private Placement	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit
Beginning Balance at Dec. 31, 2022	$ 170,475			$ 22		$ 226,580			$ (95)	$ (56,032)
Beginning Balance, Shares at Dec. 31, 2022				21,920,402
Exercise of common stock options, Shares				232
Stock-based compensation expense	2,646					2,646
Unrealized gain (loss) on available-for-sale investments, net of tax	104								104
Net Income (Loss)	(12,756)									(12,756)
Ending Balance at Mar. 31, 2023	160,469			$ 22		229,226			9	(68,788)
Ending Balance, Shares at Mar. 31, 2023				21,920,634
Beginning Balance at Dec. 31, 2022	170,475			$ 22		226,580			(95)	(56,032)
Beginning Balance, Shares at Dec. 31, 2022				21,920,402
Unrealized gain (loss) on available-for-sale investments, net of tax	(332)
Net Income (Loss)	(26,670)
Ending Balance at Jun. 30, 2023	149,184			$ 22		232,291			(427)	(82,702)
Ending Balance, Shares at Jun. 30, 2023				22,068,660
Beginning Balance at Mar. 31, 2023	160,469			$ 22		229,226			9	(68,788)
Beginning Balance, Shares at Mar. 31, 2023				21,920,634
Exercise of common stock options	379					379
Exercise of common stock options, Shares				148,026
Stock-based compensation expense	2,686					2,686
Unrealized gain (loss) on available-for-sale investments, net of tax	(436)								(436)
Net Income (Loss)	(13,914)									(13,914)
Ending Balance at Jun. 30, 2023	149,184			$ 22		232,291			(427)	(82,702)
Ending Balance, Shares at Jun. 30, 2023				22,068,660
Beginning Balance at Dec. 31, 2023	121,195			$ 23		237,675			(83)	(116,420)
Beginning Balance, Shares at Dec. 31, 2023				22,522,644
Exercise of common stock options	79					79
Exercise of common stock options, Shares				20,277
Issuance of common stock upon vesting of restricted stock units, net of shares withheld for tax	(166)					(166)
Issuance of common stock upon vesting of restricted stock units, net of shares withheld for tax, Shares				94,618
Stock-based compensation expense	3,344					3,344
Unrealized gain (loss) on available-for-sale investments, net of tax	13								13
Net Income (Loss)	(16,486)									(16,486)
Ending Balance at Mar. 31, 2024	107,979			$ 23		240,932			(70)	(132,906)
Ending Balance, Shares at Mar. 31, 2024				22,637,539
Beginning Balance at Dec. 31, 2023	$ 121,195			$ 23		237,675			(83)	(116,420)
Beginning Balance, Shares at Dec. 31, 2023				22,522,644
Exercise of common stock options, Shares	30,875
Unrealized gain (loss) on available-for-sale investments, net of tax	$ 64
Net Income (Loss)	(35,284)
Ending Balance at Jun. 30, 2024	216,058			$ 31		367,750			(19)	(151,704)
Ending Balance, Shares at Jun. 30, 2024				30,966,255
Beginning Balance at Mar. 31, 2024	107,979			$ 23		240,932			(70)	(132,906)
Beginning Balance, Shares at Mar. 31, 2024				22,637,539
Issuance of common stock in private placement, net of issuance costs		$ 66,637			$ 8		$ 66,629
Issuance of common stock in private placement, net of issuance costs, Shares					8,235,000
Issuance of pre-funded warrants in private placement, net of issuance costs			$ 57,122					$ 57,122
Exercise of common stock options	11					11
Exercise of common stock options, Shares				10,598
Issuance of common stock upon vesting of restricted stock units, net of shares withheld for tax	(510)					(510)
Issuance of common stock upon vesting of restricted stock units, net of shares withheld for tax, Shares				83,118
Stock-based compensation expense	3,566					3,566
Unrealized gain (loss) on available-for-sale investments, net of tax	51								51
Net Income (Loss)	(18,798)									(18,798)
Ending Balance at Jun. 30, 2024	$ 216,058			$ 31		$ 367,750			$ (19)	$ (151,704)
Ending Balance, Shares at Jun. 30, 2024				30,966,255

Summary of Significant Accounting Policies - Additional Information (Details)	6 Months Ended
	Jun. 30, 2024
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]	true
Change in Accounting Principle, Accounting Standards Update, Adoption Date	Jan. 01, 2024
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]	true
Accounting Standards Update [Extensible Enumeration]	us-gaap:AccountingStandardsUpdate202307Member

- Definition

Indicates amendment to accounting standards.

+ References

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-Topic 815
-SubTopic 40
-Name Accounting Standards Codification
-Section 65
-Paragraph 1
-Subparagraph (a)(1)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480175/815-40-65-1

Reference 88: http://www.xbrl.org/2003/role/disclosureRef
-Topic 815
-SubTopic 40
-Name Accounting Standards Codification
-Section 65
-Paragraph 1
-Subparagraph (a)(2)
-Publisher FASB
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Reference 89: http://www.xbrl.org/2003/role/disclosureRef
-Topic 815
-SubTopic 40
-Name Accounting Standards Codification
-Section 65
-Paragraph 1
-Subparagraph (a)(3)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480175/815-40-65-1

Reference 90: http://www.xbrl.org/2003/role/disclosureRef
-Topic 815
-SubTopic 40
-Name Accounting Standards Codification
-Section 65
-Paragraph 1
-Subparagraph (b)(1)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480175/815-40-65-1

Reference 91: http://www.xbrl.org/2003/role/disclosureRef
-Topic 815
-SubTopic 40
-Name Accounting Standards Codification
-Section 65
-Paragraph 1
-Subparagraph (b)(2)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480175/815-40-65-1

Reference 92: http://www.xbrl.org/2003/role/disclosureRef
-Topic 815
-SubTopic 40
-Name Accounting Standards Codification
-Section 65
-Paragraph 1
-Subparagraph (c)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480175/815-40-65-1

Reference 93: http://www.xbrl.org/2003/role/disclosureRef
-Topic 815
-SubTopic 40
-Name Accounting Standards Codification
-Section 65
-Paragraph 1
-Subparagraph (d)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480175/815-40-65-1

Reference 94: http://www.xbrl.org/2003/role/disclosureRef
-Topic 815
-SubTopic 40
-Name Accounting Standards Codification
-Section 65
-Paragraph 1
-Subparagraph (e)(2)
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-URI https://asc.fasb.org/1943274/2147480175/815-40-65-1

Reference 95: http://www.xbrl.org/2003/role/disclosureRef
-Topic 815
-SubTopic 40
-Name Accounting Standards Codification
-Section 65
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-Subparagraph (e)(3)
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Reference 96: http://www.xbrl.org/2003/role/disclosureRef
-Topic 815
-SubTopic 40
-Name Accounting Standards Codification
-Section 65
-Paragraph 1
-Subparagraph (e)(4)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480175/815-40-65-1

Reference 97: http://www.xbrl.org/2003/role/disclosureRef
-Topic 815
-SubTopic 40
-Name Accounting Standards Codification
-Section 65
-Paragraph 1
-Subparagraph (f)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480175/815-40-65-1

Reference 98: http://www.xbrl.org/2003/role/disclosureRef
-Topic 946
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 3
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480424/946-10-50-3

Reference 99: http://www.xbrl.org/2003/role/disclosureRef
-Topic 350
-SubTopic 60
-Name Accounting Standards Codification
-Section 65
-Paragraph 1
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147476166/350-60-65-1

Reference 100: http://www.xbrl.org/2003/role/disclosureRef
-Topic 350
-SubTopic 60
-Name Accounting Standards Codification
-Section 65
-Paragraph 1
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147476166/350-60-65-1

+ Details

Leases - Additional Information (Details) - USD ($) $ in Millions	1 Months Ended			6 Months Ended
	Dec. 31, 2023	May 31, 2021	Apr. 30, 2021	Jun. 30, 2024	Jun. 30, 2023
Lessee Lease Description [Line Items]
Weighted-average remaining lease term	4 years 2 months 12 days			3 years 8 months 12 days
Weighted-average discount rate	8.30%			8.29%
Cash paid for measurement of lease liabilities				$ 0.6	$ 0.5
Arsenal Way Lease
Lessee Lease Description [Line Items]
Lessee, operating lease, commencement month and year			2021-04
Lessee operating lease, renewal term			5 years
Lessee, operating lease, option to extend				The lease commenced in April 2021, with a term of seven years and an option to extend the term for an additional five years.
Lessee, Operating Lease, Existence of Option to Extend [true false]			true
Letter of credit			$ 0.3
Base rent			$ 1.0
Annual rent increase percentage			3.00%
Sublease expiration, month and year		2023-03
Lund, Sweden
Lessee Lease Description [Line Items]
Lessee, operating lease, commencement month and year	2023-12
Lessee operating lease, renewal term	3 years
Lessee, operating lease, initial term	3 years
Lessee, Operating Lease, Existence of Option to Extend [true false]	true

Stock-Based Compensation - Summary of Stock Option Activity (Details) $ / shares in Units, $ in Thousands	6 Months Ended	12 Months Ended
	Jun. 30, 2024 USD ($) $ / shares shares	Dec. 31, 2023 USD ($) $ / shares shares
Share-Based Payment Arrangement [Abstract]
Number of Shares, Outstanding, beginning of period \| shares	3,117,042
Number of Shares, Granted \| shares	1,360,308
Number of Shares, Exercised \| shares	(30,875)
Number of Shares, Forfeited or canceled \| shares	(89,704)
Number of Shares, Outstanding, Ending of period \| shares	4,356,771	3,117,042
Number of Shares, Vested and expected to vest, Ending of period \| shares	4,356,771
Number of Shares, Vested and exercisable, Ending of period \| shares	1,610,962
Weighted-Average Exercise Price, Outstanding, beginning of period \| $ / shares	$ 7.04
Weighted-Average Exercise Price, Granted \| $ / shares	5.67
Weighted-Average Exercise Price, Exercised \| $ / shares	2.91
Weighted-Average Exercise Price, Fortified or canceled \| $ / shares	4.04
Weighted-Average Exercise Price, Outstanding, ending of period \| $ / shares	6.7	$ 7.04
Weighted-Average Exercise Price, Vested and expected to vest, ending of period \| $ / shares	6.7
Weighted-Average Exercise Price, Vested and exercisable, ending of period \| $ / shares	$ 5.76
Weighted Average Remaining Contractual Term (in years), Outstanding	8 years 5 months 12 days	8 years 4 months 2 days
Weighted Average Remaining Contractual Term (in years), Vested and expected to vest, ending of period	8 years 5 months 12 days
Weighted Average Remaining Contractual Term (in years), Vested and exercisable, ending of period	7 years 7 months 13 days
Aggregate Intrinsic Value \| $	$ 5,006	$ 3,409
Aggregate Intrinsic Value, Vested and expected to vest, ending of period \| $	5,006
Aggregate Intrinsic Value, Vested and exercisable, ending of period \| $	$ 3,472

Pay vs Performance Disclosure - USD ($) $ in Thousands	3 Months Ended				6 Months Ended
Pay vs Performance Disclosure - USD ($) $ in Thousands	Jun. 30, 2024	Mar. 31, 2024	Jun. 30, 2023	Mar. 31, 2023	Jun. 30, 2024	Jun. 30, 2023
Pay vs Performance Disclosure
Net Income (Loss)	$ (18,798)	$ (16,486)	$ (13,914)	$ (12,756)	$ (35,284)	$ (26,670)

- Definition

The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 250
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-Name Accounting Standards Codification
-Section 50
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-URI https://asc.fasb.org/1943274/2147483443/250-10-50-6

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
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-URI https://asc.fasb.org/1943274/2147483443/250-10-50-9

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
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-Name Accounting Standards Codification
-Section 65
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Reference 4: http://www.xbrl.org/2003/role/disclosureRef
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-Section 65
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-Publisher FASB
-URI https://asc.fasb.org/1943274/2147478666/740-323-65-2

Reference 5: http://fasb.org/us-gaap/role/ref/legacyRef
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-Section S99
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Reference 6: http://www.xbrl.org/2003/role/disclosureRef
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Reference 7: http://www.xbrl.org/2003/role/disclosureRef
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Reference 8: http://www.xbrl.org/2003/role/disclosureRef
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Reference 9: http://www.xbrl.org/2003/role/disclosureRef
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Reference 10: http://www.xbrl.org/2003/role/disclosureRef
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Reference 12: http://www.xbrl.org/2003/role/disclosureRef
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Reference 13: http://www.xbrl.org/2003/role/disclosureRef
-Topic 250
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Reference 14: http://www.xbrl.org/2003/role/disclosureRef
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Reference 15: http://www.xbrl.org/2003/role/disclosureRef
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Reference 16: http://www.xbrl.org/2003/role/disclosureRef
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Reference 18: http://www.xbrl.org/2003/role/disclosureRef
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Reference 20: http://www.xbrl.org/2003/role/disclosureRef
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Reference 36: http://www.xbrl.org/2003/role/disclosureRef
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Reference 37: http://fasb.org/us-gaap/role/ref/legacyRef
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-URI https://asc.fasb.org/1943274/2147478524/942-220-S99-1

+ Details

Commitments and Contingencies - Additional Information (Details) - USD ($)	1 Months Ended		3 Months Ended		6 Months Ended		25 Months Ended
	Jun. 30, 2022	Jan. 31, 2021	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024
Lilly Agreement
Loss Contingencies [Line Items]
Upfront payment		$ 5,000,000
Royalties incurred					$ 0
Lilly Agreement \| Maximum
Loss Contingencies [Line Items]
Tiered percentage royalty on annual net sales		10.00%
Akoya Agreement
Loss Contingencies [Line Items]
Upfront payment	$ 600,000
Obligation to pay upon achievement of specified development milestones	$ 17,300,000
Milestone payments							$ 10,100,000
Milestones expenses				$ 0
Research and Development Expense \| Akoya Agreement
Loss Contingencies [Line Items]
Milestones expenses			$ 1,800,000		$ 1,800,000	$ 1,500,000
Development and Commercial Milestone \| Lilly Agreement
Loss Contingencies [Line Items]
Milestone payments		$ 168,000,000

Stock-Based Compensation

6 Months Ended

Jun. 30, 2024

Share-Based Payment Arrangement [Abstract]

Stock-Based Compensation

9. Stock-Based Compensation

Equity Incentive Plans

In October 2022, the Board adopted, and in November 2022 its stockholders approved, the 2022 Plan, which replaced the 2019 Plan and became effective immediately prior to and contingent upon the execution of the underwriting agreement related to the Company’s IPO. The 2022 Plan allows the Company to make equity-based and cash-based incentive awards to its officers, employees, directors, and consultants and provides for the grant of incentive stock options, non-qualified stock options, stock appreciation rights, restricted stock awards, restricted stock units (“RSUs”) and other stock-based awards. In addition, the number of shares reserved and available for issuance under the 2022 Plan shall automatically increase beginning on January 1, 2023 and each January 1 thereafter, by five percent of the aggregate number of shares of common stock of all classes issued and outstanding on the immediately preceding December 31 or such lesser number of shares of common stock as determined by the compensation committee.

In October 2022, the Board adopted, and in November 2022 its stockholders approved, the 2022 ESPP, which became effective immediately prior to and contingent upon the execution of the underwriting agreement related to the Company’s IPO. The number of

shares of common stock that may be issued under the 2022 ESPP shall cumulatively increase beginning on January 1, 2023 and each January 1 thereafter through January 1, 2032, by one percent of the outstanding number of shares of common stock on the immediately preceding December 31 or such lesser number of shares as determined by the compensation committee. No shares of the Company's common stock have been issued and no stock-based compensation expense has been recognized related to the 2022 ESPP.

In June 2023, the Board adopted the Inducement Plan to facilitate the granting of equity awards as an inducement material to new employees joining the Company. The only persons eligible to receive awards under the Inducement Plan are individuals who are new employees and satisfy the standards for inducement grants under Nasdaq Listing Rule 5635(c)(4) or 5635(c)(3), as applicable. The terms of the Inducement Plan are identical to the terms of the 2022 Plan, except that no incentive stock options shall be awarded under the Inducement Plan.

Stock Options

The Company has granted stock options with service-based vesting conditions. Stock options typically vest over four years and have a maximum term of ten years. The Company typically grants stock options to employees and non-employees at exercise prices deemed by the Board to be equal to the fair value of the common stock at the time of grant.

The assumptions that the Company used in the Black-Scholes option-pricing model to determine the grant date fair value of stock options granted were as follows:


	Six Months Ended June 30,
	2024	2023
Risk-free interest rate range	3.93% - 4.57%	3.40% - 4.28%
Dividend yield	0.00%	0.00%
Expected life of options (years)	5.5 - 6.1	5.8 - 6.1
Volatility rate range	81.06% - 82.31%	82.62% - 83.55%
Fair value of common stock range	$3.54 - $8.65	$11.95 - $20.50

The following table summarizes the Company’s stock option activity:


	Number of Shares			Weighted-Average Exercise Price		Weighted-Average Remaining Contractual Term (in years)		Aggregate Intrinsic Value (in thousands)
Outstanding as of December 31, 2023		3,117,042		$	7.04		8.34	$	3,409
Granted		1,360,308			5.67
Exercised		(30,875	)		2.91
Forfeited or canceled		(89,704	)		4.04
Outstanding as of June 30, 2024		4,356,771		$	6.70		8.45	$	5,006
Vested and expected to vest as of June 30, 2024		4,356,771		$	6.70		8.45	$	5,006
Vested and exercisable as of June 30, 2024		1,610,962		$	5.76		7.62	$	3,472

The aggregate intrinsic value of options is calculated as the difference between the exercise price of the stock options and the fair value of the Company’s common stock for those stock options that had exercise prices lower than the fair value of the common stock as of the end of the reporting period. The aggregate intrinsic value of options exercised during the six months ended June 30, 2024 and 2023 was $0.1 million and $1.5 million, respectively.

The weighted-average grant date fair value of the Company’s stock options granted during the three months ended June 30, 2024 and 2023 was $4.91 and $8.92 per option, respectively. The weighted-average grant date fair value of the Company’s stock options granted during the six months ended June 30, 2024 and 2023 was $4.10 and $10.49 per option, respectively. As of June 30, 2024, there was $13.5 million of unrecognized stock-based compensation expense related to stock option grants. The Company expects to recognize this amount over a weighted-average period of 2.6 years.

The total fair value of options vested during the three months ended June 30, 2024 and 2023 was $1.0 million and $0.5 million, respectively. The total fair value of options vested during the six months ended June 30, 2024 and 2023 was $2.0 million and $0.8 million, respectively.

RSUs

The Company has granted RSUs with service vesting based conditions. Unvested shares of restricted common stock may not be sold or transferred by the holder. They are legally issued and outstanding. These restrictions lapse according to the time-based vesting of each award.

A summary of the RSU activity during the six months ended June 30, 2024 is as follows:


	Restricted Stock Units			Weighted-Average Grant Date Fair Value
Unvested at December 31, 2023		1,759,918		$	12.09
Vested		(287,177	)		12.53
Unvested at June 30, 2024		1,472,741		$	12.01

RSUs typically vest over four years. If and when an RSU vests, the Company will issue one share of common stock for each whole RSU that has vested, subject to satisfaction of the employee's tax withholding obligations. Upon vesting and settlement of RSUs, the Company may withhold the portion of those shares with a fair market value equal to the amount of the minimum statutory withholding taxes due. The withheld shares are accounted for as repurchases of common stock.

No RSUs were granted during the three and six months ended June 30, 2024. The weighted-average grant date fair value of the Company’s RSUs granted during the three and six months ended June 30, 2023 was $11.97 and $15.10 per RSU, respectively. As of June 30, 2024, there was $15.1 million of unrecognized stock-based compensation expense related to RSUs. The Company expects to recognize this amount over a weighted-average period of 1.8 years.

The total fair value of RSUs vested during the three and six months ended June 30, 2024 was $1.8 million and $3.6 million, respectively. No RSUs vested during the three and six months ended June 30, 2023.

Stock-Based Compensation Expense

Stock-based compensation expense included in the Company’s condensed consolidated statements of operations and comprehensive loss is as follows (in thousands):


	Three Months Ended June 30,				Six Months Ended June 30,
	2024		2023		2024		2023
General and administrative	$	2,788	$	2,075	$	5,454	$	4,095
Research and development		778		611		1,456		1,237
Total stock-based compensation expense	$	3,566	$	2,686	$	6,910	$	5,332

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (UNAUDITED) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023
Operating expenses:
Research and development	$ 15,025	$ 10,521	$ 26,498	$ 20,279
General and administrative	6,412	4,999	12,607	9,634
Total operating expenses	21,437	15,520	39,105	29,913
Loss from operations	(21,437)	(15,520)	(39,105)	(29,913)
Other income (expense), net:
Interest income	2,694	1,770	4,140	3,577
Other expense, net	(55)	(164)	(319)	(334)
Total other income, net	2,639	1,606	3,821	3,243
Net loss	$ (18,798)	$ (13,914)	$ (35,284)	$ (26,670)
Net loss per share—basic	$ (0.52)	$ (0.63)	$ (1.2)	$ (1.22)
Net loss per share—diluted	$ (0.52)	$ (0.63)	$ (1.2)	$ (1.22)
Weighted-average common stock outstanding—basic	36,132,616	21,971,032	29,361,710	21,945,940
Weighted-average common stock outstanding—diluted	36,132,616	21,971,032	29,361,710	21,945,940
Comprehensive loss:
Net Income (Loss)	$ (18,798)	$ (13,914)	$ (35,284)	$ (26,670)
Other comprehensive income (loss):
Unrealized gain (loss) on available-for-sale investments, net of tax	51	(436)	64	(332)
Comprehensive loss	$ (18,747)	$ (14,350)	$ (35,220)	$ (27,002)

Fair Value Measurements - Summary of Financial Assets Measured at Fair Value on Recurring Basis (Detail) - USD ($) $ in Thousands	Jun. 30, 2024	Dec. 31, 2023
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Short-term investments		$ 91,443
US Treasury Securities
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Short-term investments	$ 134,531	41,473
Long-term investments	39,895
US Government-Sponsored Enterprises Securities
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Short-term investments		49,970
Recurring
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total assets measured at fair value	211,311	122,634
Recurring \| Money Market Funds
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Cash and cash equivalents, fair value	36,885	31,191
Recurring \| US Treasury Securities
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Short-term investments	134,531	41,473
Long-term investments	39,895
Recurring \| US Government-Sponsored Enterprises Securities
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Short-term investments		49,970
Recurring \| Level 1
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total assets measured at fair value	211,311	72,664
Recurring \| Level 1 \| Money Market Funds
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Cash and cash equivalents, fair value	36,885	31,191
Recurring \| Level 1 \| US Treasury Securities
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Short-term investments	134,531	41,473
Long-term investments	$ 39,895
Recurring \| Level 2
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Total assets measured at fair value		49,970
Recurring \| Level 2 \| US Government-Sponsored Enterprises Securities
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Short-term investments		$ 49,970

Property and Equipment, Net

6 Months Ended

Jun. 30, 2024

Property, Plant and Equipment [Abstract]

Property and Equipment, Net

5. Property and Equipment, net

Property and equipment, net consisted of the following (in thousands):


	June 30, 2024			December 31, 2023
Laboratory and computer equipment	$	4,584		$	2,955
Furniture and fixtures		172			172
Construction in progress		119			1,308
Total property and equipment		4,875			4,435
Less: accumulated depreciation		(1,408	)		(956	)
Total property and equipment, net	$	3,467		$	3,479

Depreciation expense related to property and equipment for the three months ended June 30, 2024 and 2023 was $0.2 million and $0.1 million, respectively. Depreciation expense related to property and equipment for the six months ended June 30, 2024 and 2023 was $0.5 million and $0.3 million, respectively.

Stockholders' Equity

6 Months Ended

Jun. 30, 2024

Class of Stock Disclosures [Abstract]

Stockholders' Equity

8. Stockholders' Equity

Prior to the IPO, the voting, dividend and liquidation rights of the holders of the Company’s common stock were subject to and qualified by the rights, powers and preferences of the holders of the Preferred Stock as set forth above and described in the Company’s final prospectus for the IPO filed with the SEC pursuant to Rule 424(b)(4) under the Securities Act on November 16, 2022.

In October 2022, the Board approved the amended and restated certificate of incorporation, which was filed upon the closing of the IPO and which authorized the Company to issue up to 10,000,000 shares of preferred stock, with a par value of $0.001. There are no shares of preferred stock issued or outstanding as of June 30, 2024.

As of June 30, 2024 and December 31, 2023, the Company’s Amended and Restated Certificate of Incorporation authorized the Company to issue 500,000,000 shares of common stock with a par value of $0.001.

The holders of the common stock are entitled to one vote for each share of common stock held at all meetings of stockholders (and written actions in lieu of meetings), and there are not any cumulative voting rights. The number of authorized shares of common stock may be increased or decreased by the affirmative vote of the holders of shares of capital stock of the Company; however, the issuance of common stock may be subject to the vote of the holders of one or more series of preferred stock that may be required by terms of the Amended and Restated Certificate of Incorporation.

PIPE Securities Purchase Agreement

On April 8, 2024, the Company entered into the PIPE Purchase Agreement for a private placement with certain institutional and accredited investors. Pursuant to the PIPE Purchase Agreement, the Company agreed to issue and sell to the PIPE investors an aggregate of (i) 8,235,000 shares of the Company’s common stock at a purchase price of $8.50 per share, and (ii) Pre-Funded Warrants to purchase up to an aggregate of 7,060,000 shares of the Company’s common stock at a purchase price of $8.499 per Pre-Funded Warrant, which represents the per share purchase price of the Company’s common stock less the $0.001 per share exercise price for each Pre-Funded Warrant. The Pre-Funded Warrants are exercisable at any time after the date of issuance and do not expire.

The holders of Pre-Funded Warrants may not exercise a Pre-Funded Warrant if the holder, together with its affiliates, would beneficially own more than 4.99% of the number of shares of common stock outstanding immediately after giving effect to such exercise. The holders of Pre-Funded Warrants may increase or decrease such percentage by providing at least 61 days’ prior notice to the Company, but not in excess of 19.99% in the case of an increase. The Pre-Funded Warrants are indexed to the Company's common stock and were classified as a component of permanent equity in the Company's condensed consolidated balance sheet as they are freestanding financial instruments that are immediately exercisable, do not embody an obligation for the Company to repurchase its own shares and permit the holders to receive a fixed number of shares of common stock upon exercise. The April 2024 Private Placement closed on April 11, 2024, for aggregate net proceeds of $123.8 million, after deducting fees and expenses of $6.2 million. As of June 30, 2024, no Pre-Funded Warrants were exercised.

Common Stock


	June 30, 2024		December 31, 2023
Options to purchase common stock		4,356,771		3,117,042
Pre-funded warrants to purchase common stock		7,060,000		—
Unvested restricted stock units		1,472,741		1,759,918
Remaining shares reserved for future issuance		2,297,940		2,107,745
Total		15,187,452		6,984,705

- Definition

The entire disclosure for equity.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 13
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481112/505-10-50-13

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 13
-Subparagraph (h)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481112/505-10-50-13

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 14
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481112/505-10-50-14

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Topic 946
-SubTopic 235
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147477968/946-235-50-2

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Topic 946
-SubTopic 235
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (d)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147477968/946-235-50-2

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Topic 946
-SubTopic 505
-Name Accounting Standards Codification
-Section 50
-Paragraph 6
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147478448/946-505-50-6

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Topic 815
-SubTopic 40
-Name Accounting Standards Codification
-Section 50
-Paragraph 6
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480237/815-40-50-6

Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.3-04)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480008/505-10-S99-1

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Topic 235
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08(e)(1))
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480678/235-10-S99-1

Reference 10: http://fasb.org/us-gaap/role/ref/legacyRef
-Topic 505
-Name Accounting Standards Codification
-Publisher FASB
-URI https://asc.fasb.org/505/tableOfContent

Reference 11: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
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-URI https://asc.fasb.org/1943274/2147481112/505-10-50-13

Reference 12: http://www.xbrl.org/2003/role/disclosureRef
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-Paragraph 13
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-URI https://asc.fasb.org/1943274/2147481112/505-10-50-13

Reference 13: http://www.xbrl.org/2003/role/disclosureRef
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-Section 50
-Paragraph 13
-Subparagraph (i)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481112/505-10-50-13

Reference 14: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
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-Name Accounting Standards Codification
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-Paragraph 14
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481112/505-10-50-14

Reference 15: http://www.xbrl.org/2003/role/disclosureRef
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Reference 16: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
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Reference 17: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
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-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481112/505-10-50-18

Reference 18: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
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-Name Accounting Standards Codification
-Section 50
-Paragraph 18
-Subparagraph (b)
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Reference 19: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
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-Section 50
-Paragraph 18
-Subparagraph (d)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481112/505-10-50-18

+ Details

Net Loss Per Share (Tables)

6 Months Ended

Jun. 30, 2024

Earnings Per Share [Abstract]

Schedule of Computation of Basic and Diluted Net Loss Per Share

Basic and diluted net loss per share attributable to common stockholders was calculated as follows (in thousands, except share and per share amounts):


	Three Months Ended June 30,						Six Months Ended June 30,
	2024			2023			2024			2023
Numerator:
Net loss attributable to common stockholders—basic and diluted	$	(18,798	)	$	(13,914	)	$	(35,284	)	$	(26,670	)
Denominator:
Weighted-average common stock outstanding—basic and diluted		36,132,616			21,971,032			29,361,710			21,945,940
Net loss per share—basic and diluted	$	(0.52	)	$	(0.63	)	$	(1.20	)	$	(1.22	)

Summary of Potentially Dilutive Securities

The Company excluded the following shares from the computation of diluted net loss per share attributable to common stockholders as of June 30, 2024 and 2023 because including them would have had an anti-dilutive effect:


	June 30,
	2024		2023
Options to purchase common stock		4,356,771		3,130,630
Unvested restricted stock units		1,472,741		1,805,055

Property and Equipment, Net (Tables)

6 Months Ended

Jun. 30, 2024

Property, Plant and Equipment [Abstract]

Schedule of Property and Equipment, Net

Property and equipment, net consisted of the following (in thousands):


	June 30, 2024			December 31, 2023
Laboratory and computer equipment	$	4,584		$	2,955
Furniture and fixtures		172			172
Construction in progress		119			1,308
Total property and equipment		4,875			4,435
Less: accumulated depreciation		(1,408	)		(956	)
Total property and equipment, net	$	3,467		$	3,479

Net Loss per Share - Additional Information (Details) - PIPE Securities Purchase Agreement - Pre-Funded Warrants	Apr. 08, 2024 $ / shares shares
Earnings Per Share [Line Items]
Shares of common stock issuable upon exercise of warrants	7,060,000
Purchase price per Warrant \| $ / shares	$ 8.499
Maximum
Earnings Per Share [Line Items]
Shares of common stock issuable upon exercise of warrants	7,060,000

Leases - Schedule of Future Minimum Annual Lease Commitments under Non-cancellable Operating Leases (Details) - USD ($) $ in Thousands	Jun. 30, 2024	Dec. 31, 2023
Leases [Abstract]
2024 (remaining 6 months)	$ 633
2025	1,306
2026	1,340
2027	1,200
2028	404
Total lease payments	4,883
Less: interest	(662)
Present value of operating lease liabilities	$ 4,221	$ 4,644

Property and Equipment, Net - Schedule of Property and Equipment, Net (Details) - USD ($) $ in Thousands	Jun. 30, 2024	Dec. 31, 2023
Property Plant And Equipment [Line Items]
Total property and equipment	$ 4,875	$ 4,435
Less: accumulated depreciation	(1,408)	(956)
Total property and equipment, net	3,467	3,479
Laboratory and Computer Equipment
Property Plant And Equipment [Line Items]
Total property and equipment	4,584	2,955
Furniture and Fixtures
Property Plant And Equipment [Line Items]
Total property and equipment	172	172
Construction in Progress
Property Plant And Equipment [Line Items]
Total property and equipment	$ 119	$ 1,308

Net Loss Per Share - Schedule of Computation of Basic and Diluted Net Loss Per Share (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended				6 Months Ended
	Jun. 30, 2024	Mar. 31, 2024	Jun. 30, 2023	Mar. 31, 2023	Jun. 30, 2024	Jun. 30, 2023
Comprehensive loss:
Net loss attributable to common stockholders - basic and diluted	$ (18,798)	$ (16,486)	$ (13,914)	$ (12,756)	$ (35,284)	$ (26,670)
Denominator:
Weighted-average common stock outstanding—basic	36,132,616		21,971,032		29,361,710	21,945,940
Weighted-average common stock outstanding—diluted	36,132,616		21,971,032		29,361,710	21,945,940
Net loss per share—basic	$ (0.52)		$ (0.63)		$ (1.2)	$ (1.22)
Net loss per share—diluted	$ (0.52)		$ (0.63)		$ (1.2)	$ (1.22)

- Definition

The amount of net income (loss) for the period per each share of common stock or unit outstanding during the reporting period.

+ References

+ Details

- Definition

The amount of net income (loss) for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period.

+ References

+ Details

- Definition

The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

+ References

+ Details

Accrued Expenses and Other Current Liabilities (Tables)

6 Months Ended

Jun. 30, 2024

Payables and Accruals [Abstract]

Summary of Accrued Expenses and Other Current Liabilities

Accrued expenses and other current liabilities consisted of the following (in thousands):


	June 30, 2024		December 31, 2023
Accrued research and development expenses	$	5,069	$	2,661
Accrued compensation and benefits		2,947		3,860
Accrued legal, accounting and other professional fees		600		667
Accrued offering costs		283		—
Accrued other		146		190
Total accrued expenses and other current liabilities	$	9,045	$	7,378

Stock-Based Compensation - Summary of RSU activity (Details)	6 Months Ended
	Jun. 30, 2024 $ / shares shares
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Restricted Stock Units, Unvested at December 31, 2023	1,759,918
Restricted Stock Units, Unvested at June 30, 2024	1,472,741
RSUs
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Restricted Stock Units, Unvested at December 31, 2023	1,759,918
Restricted Stock Units, Vested	(287,177)
Restricted Stock Units, Unvested at June 30, 2024	1,472,741
Weighted-Average Grant Date Fair Value, Unvested at December 31, 2023 \| $ / shares	$ 12.09
Weighted-Average Grant Date Fair Value, Vested \| $ / shares	12.53
Weighted-Average Grant Date Fair Value, Unvested at June 30, 2024 \| $ / shares	$ 12.01

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 35
-Paragraph 1D
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480483/718-10-35-1D

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
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-Name Accounting Standards Codification
-Section 35
-Paragraph 3
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480483/718-10-35-3

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
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-Paragraph 2
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-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480429/718-10-50-2

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
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Reference 5: http://www.xbrl.org/2003/role/disclosureRef
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Reference 6: http://www.xbrl.org/2003/role/disclosureRef
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Reference 7: http://www.xbrl.org/2003/role/disclosureRef
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Reference 8: http://www.xbrl.org/2003/role/disclosureRef
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Reference 9: http://www.xbrl.org/2003/role/disclosureRef
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Reference 13: http://www.xbrl.org/2003/role/disclosureRef
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Reference 14: http://www.xbrl.org/2003/role/disclosureRef
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+ Details

Stock-Based Compensation (Tables)

6 Months Ended

Jun. 30, 2024

Share-Based Payment Arrangement [Abstract]

Assumptions of Grant Date Fair Value of Stock Options Granted

The assumptions that the Company used in the Black-Scholes option-pricing model to determine the grant date fair value of stock options granted were as follows:


	Six Months Ended June 30,
	2024	2023
Risk-free interest rate range	3.93% - 4.57%	3.40% - 4.28%
Dividend yield	0.00%	0.00%
Expected life of options (years)	5.5 - 6.1	5.8 - 6.1
Volatility rate range	81.06% - 82.31%	82.62% - 83.55%
Fair value of common stock range	$3.54 - $8.65	$11.95 - $20.50

Summary of Stock Option Activity

The following table summarizes the Company’s stock option activity:


	Number of Shares			Weighted-Average Exercise Price		Weighted-Average Remaining Contractual Term (in years)		Aggregate Intrinsic Value (in thousands)
Outstanding as of December 31, 2023		3,117,042		$	7.04		8.34	$	3,409
Granted		1,360,308			5.67
Exercised		(30,875	)		2.91
Forfeited or canceled		(89,704	)		4.04
Outstanding as of June 30, 2024		4,356,771		$	6.70		8.45	$	5,006
Vested and expected to vest as of June 30, 2024		4,356,771		$	6.70		8.45	$	5,006
Vested and exercisable as of June 30, 2024		1,610,962		$	5.76		7.62	$	3,472

Summary of RSU activity

A summary of the RSU activity during the six months ended June 30, 2024 is as follows:


	Restricted Stock Units			Weighted-Average Grant Date Fair Value
Unvested at December 31, 2023		1,759,918		$	12.09
Vested		(287,177	)		12.53
Unvested at June 30, 2024		1,472,741		$	12.01

Summary of Share-based Compensation Expense

Stock-based compensation expense included in the Company’s condensed consolidated statements of operations and comprehensive loss is as follows (in thousands):


	Three Months Ended June 30,				Six Months Ended June 30,
	2024		2023		2024		2023
General and administrative	$	2,788	$	2,075	$	5,454	$	4,095
Research and development		778		611		1,456		1,237
Total stock-based compensation expense	$	3,566	$	2,686	$	6,910	$	5,332

Investments - Summary of Amortized Cost and Estimated Fair Value of Investments (Details) - USD ($) $ in Thousands	Jun. 30, 2024	Dec. 31, 2023
Debt Securities, Available-for-Sale [Line Items]
Amortized Cost	$ 174,445
Gross Unrealized Gains	41
Gross Unrealized Losses	(60)
Fair Value	174,426
Amortization Cost, Short-term investments		$ 91,526
Gross Unrealized Gains, Short-term investments		22
Gross Unrealized Losses, Short-term investments		(105)
Fair Value, Short-term investments		91,443
US Treasury Securities
Debt Securities, Available-for-Sale [Line Items]
Amortization Cost, Short-term investments	134,588	41,470
Gross Unrealized Gains, Short-term investments	3	22
Gross Unrealized Losses, Short-term investments	(60)	(19)
Fair Value, Short-term investments	134,531	41,473
Amortization Cost, Long-term investments	39,857
Gross Unrealized Gains, Long-term investments	38
Fair Value, Long-term investments	$ 39,895
US Government-Sponsored Enterprises Securities
Debt Securities, Available-for-Sale [Line Items]
Amortization Cost, Short-term investments		50,056
Gross Unrealized Losses, Short-term investments		(86)
Fair Value, Short-term investments		$ 49,970

Leases (Tables)

6 Months Ended

Jun. 30, 2024

Leases [Abstract]

Summary of Presentation of Operating Leases on Condensed Consolidated Balance Sheet

The following table summarizes the presentation of the Company’s operating leases on its condensed consolidated balance sheets (in thousands):


Leases	Balance sheet classification	June 30, 2024		December 31, 2023
Assets:
Operating lease assets	Operating lease right-of-use assets	$	3,976	$	4,429
Total lease assets		$	3,976	$	4,429
Liabilities:
Current:
Operating lease liabilities	Operating lease liability, current	$	978	$	877
Noncurrent:
Operating lease liabilities	Operating lease liability, long-term		3,243		3,767
Total lease liabilities		$	4,221	$	4,644

Schedule of Components of Lease Cost


	Three Months Ended June 30,				Six Months Ended June 30,
Lease cost	2024		2023		2024		2023
Operating lease cost	$	317	$	286	$	634	$	572
Variable lease cost		170		152		299		248
Sublease income		—		—		—		(134	)
Total lease cost	$	487	$	438	$	933	$	686

Schedule of Future Minimum Annual Lease Commitments under Non-cancellable Operating Leases

Future minimum annual lease commitments under the Company’s non-cancelable operating leases as of June 30, 2024 were as follows (in thousands):


Fiscal Year	Amount
2024 (remaining 6 months)	$	633
2025		1,306
2026		1,340
2027		1,200
2028		404
Thereafter		—
Total lease payments		4,883
Less: interest		(662	)
Present value of operating lease liabilities	$	4,221

Summary of Significant Accounting Policies (Policies)	6 Months Ended
Summary of Significant Accounting Policies (Policies)	Jun. 30, 2024
Accounting Policies [Abstract]
Pre-Funded Warrants	Pre-Funded Warrants Warrants are accounted for based on the specific terms of the warrant agreements. The Company's pre-funded warrants are indexed to the Company's common stock and meet the criteria to be classified as equity. Proceeds from the issuance of pre-funded warrants are recorded within additional paid-in capital and are not subject to remeasurement. Refer to Note 8 and Note 10 for further information regarding pre-funded warrants issued by the Company.
Unaudited Interim Financial Information	The accompanying unaudited condensed consolidated financial statements have been prepared in conformity with accounting principles generally accepted in the United States of America (“U.S. GAAP”) and include the operations of Acrivon Therapeutics, Inc. and its wholly-owned subsidiaries. All intercompany accounts, transactions and balances have been eliminated in consolidation. The accompanying condensed consolidated interim financial statements are unaudited but have been prepared on the same basis as the audited annual financial statements and, in the opinion of management, reflect all adjustments, which include only normal recurring adjustments necessary for the fair statement of the Company’s financial position as of June 30, 2024 and the results of its operations for the three and six months ended June 30, 2024 and 2023 and its cash flows for the six months ended June 30, 2024 and 2023. The consolidated balance sheet as of December 31, 2023 was derived from audited annual financial statements but does not include all disclosures required by U.S. GAAP. The results for the three and six months ended June 30, 2024 are not necessarily indicative of results to be expected for the full year or for any other subsequent interim period.
Recently Adopted Accounting Pronouncements	Recently Adopted Accounting Pronouncements ASU 2023-07, Segment Reporting (Topic 280) In November 2023, the FASB issued ASU 2023-07, Segment Reporting (Topic 280): Improvements to Reportable Segment Disclosures, which requires public entities to disclose information about their reportable segments’ significant expenses on an interim and annual basis. All disclosure requirements under ASU 2023-07 are also required for public entities with a single reportable segment. The ASU is effective for annual periods beginning after December 15, 2023 and for interim periods within fiscal years beginning after December 15, 2024. The Company adopted this accounting standard as of January 1, 2024, with no material impact on its condensed consolidated financial statements and related disclosures.

Fair Value Measurement (Tables)

6 Months Ended

Jun. 30, 2024

Summary of Financial Assets and Liabilities Measured at Fair Value on Recurring Basis


			Fair Value Measurements at June 30, 2024 Using:
Assets:	Total		Level 1		Level 2		Level 3
Cash equivalents:
Money market funds	$	36,885	$	36,885	$	—	$	—
Short-term investments:
U.S. Treasury securities		134,531		134,531		—		—
Long-term investments:
U.S. Treasury securities		39,895		39,895		—		—
Total assets	$	211,311	$	211,311	$	—	$	—


			Fair Value Measurements at December 31, 2023 Using:
Assets:	Total		Level 1		Level 2		Level 3
Cash equivalents:
Money market funds	$	31,191	$	31,191	$	—	$	—
Short-term investments:
U.S. Treasury securities		41,473		41,473		—		—
U.S. government-sponsored enterprise securities		49,970		—		49,970		—
Total assets	$	122,634	$	72,664	$	49,970	$	—

CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (UNAUDITED) (Parenthetical) - Private Placement $ in Thousands	3 Months Ended
	Jun. 30, 2024 USD ($)
Issuance costs of common stock in private placement	$ 3,360
Issuance costs of pre-funded warrants in private placement	$ 2,881

CONDENSED CONSOLIDATED BALANCE SHEETS (UNAUDITED) (Parenthetical) - $ / shares	Jun. 30, 2024	Dec. 31, 2023
Preferred stock, par value	$ 0.001	$ 0.001
Preferred stock, authorized	10,000,000	10,000,000
Preferred stock, shares, issued	0	0
Preferred stock, shares, outstanding	0	0
Common stock, per share value	$ 0.001	$ 0.001
Common stock, shares authorized	500,000,000	500,000,000
Common stock, shares, issued	30,966,255	22,522,644
Common stock, shares, outstanding	30,966,255	22,522,644

Net Loss Per Share

6 Months Ended

Jun. 30, 2024

Earnings Per Share [Abstract]

Net Loss Per Share

10. Net Loss Per Share

Basic and diluted net loss per share attributable to common stockholders was calculated as follows (in thousands, except share and per share amounts):


	Three Months Ended June 30,						Six Months Ended June 30,
	2024			2023			2024			2023
Numerator:
Net loss attributable to common stockholders—basic and diluted	$	(18,798	)	$	(13,914	)	$	(35,284	)	$	(26,670	)
Denominator:
Weighted-average common stock outstanding—basic and diluted		36,132,616			21,971,032			29,361,710			21,945,940
Net loss per share—basic and diluted	$	(0.52	)	$	(0.63	)	$	(1.20	)	$	(1.22	)

As described in Note 8, the Pre-Funded Warrants to purchase up to an aggregate of 7,060,000 shares of the Company’s common stock at a purchase price of $8.499 per Pre-Funded Warrant were classified as a component of permanent equity in the Company's condensed consolidated balance sheet as they are freestanding financial instruments that are immediately exercisable, do not embody an obligation for the Company to repurchase its own shares and permit the holders to receive a fixed number of shares of common stock upon exercise. All of the shares underlying the Pre-Funded Warrants have been included in the weighted-average number of shares of common stock used to calculate basic and diluted net loss per common share for the three and six months ended June 30, 2024, because

the shares may be issued for little or no consideration, are fully vested, and are exercisable after the original issuance date of the Pre-Funded Warrants.

The Company’s potentially dilutive securities, which include stock options and RSUs, have been excluded from the computation of diluted net loss per share as the effect would be to reduce the net loss per share. Therefore, the weighted-average number of common shares outstanding used to calculate both basic and diluted net loss per share attributable to common stockholders is the same. The Company excluded the following shares from the computation of diluted net loss per share attributable to common stockholders as of June 30, 2024 and 2023 because including them would have had an anti-dilutive effect:


	June 30,
	2024		2023
Options to purchase common stock		4,356,771		3,130,630
Unvested restricted stock units		1,472,741		1,805,055

Accrued Expenses and Other Current Liabilities

6 Months Ended

Jun. 30, 2024

Payables and Accruals [Abstract]

Accrued Expenses and Other Current Liabilities

6. Accrued Expenses and Other Current Liabilities

Accrued expenses and other current liabilities consisted of the following (in thousands):


	June 30, 2024		December 31, 2023
Accrued research and development expenses	$	5,069	$	2,661
Accrued compensation and benefits		2,947		3,860
Accrued legal, accounting and other professional fees		600		667
Accrued offering costs		283		—
Accrued other		146		190
Total accrued expenses and other current liabilities	$	9,045	$	7,378

CONDENSED CONSOLIDATED BALANCE SHEETS (UNAUDITED) - USD ($) $ in Thousands	Jun. 30, 2024	Dec. 31, 2023
Current assets:
Cash and cash equivalents	$ 46,006	$ 36,015
Short-term investments	134,531	91,443
Prepaid expenses and other current assets	1,821	2,234
Total current assets	182,358	129,692
Property and equipment, net	3,467	3,479
Operating lease right-of-use assets	3,976	4,429
Long-term investments	39,895
Restricted cash	421	414
Deferred offering costs	468	251
Total assets	230,585	138,265
Current liabilities:
Accounts payable	1,261	5,048
Accrued expenses and other current liabilities	9,045	7,378
Operating lease liabilities, current	978	877
Total current liabilities	11,284	13,303
Operating lease liabilities, long-term	3,243	3,767
Total liabilities	14,527	17,070
Commitments and contingencies (Note 11)
Stockholders’ deficit:
Common stock, $0.001 par value; 500,000,000 shares authorized as of June 30, 2024 and December 31, 2023; 30,966,255 and 22,522,644 shares issued and outstanding as of June 30, 2024 and December 31, 2023, respectively.	31	23
Additional paid-in capital	367,750	237,675
Accumulated other comprehensive loss	(19)	(83)
Accumulated deficit	(151,704)	(116,420)
Total stockholders' equity	216,058	121,195
Total liabilities and stockholders' equity	$ 230,585	$ 138,265

Stock-Based Compensation - Summary of Share-based Compensation Expense (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Total stock-based compensation expense	$ 3,566	$ 2,686	$ 6,910	$ 5,332
General and Administrative Expense
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Total stock-based compensation expense	2,788	2,075	5,454	4,095
Research and Development Expense
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Total stock-based compensation expense	$ 778	$ 611	$ 1,456	$ 1,237

Stock-Based Compensation - Additional Information (Details) - USD ($)	1 Months Ended	3 Months Ended		6 Months Ended
	Oct. 31, 2022	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023	Dec. 31, 2023
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of shares reserved for issuance		2,297,940		2,297,940		2,107,745
Options outstanding		4,356,771		4,356,771		3,117,042
Stock-based compensation expense		$ 3,566,000	$ 2,686,000	$ 6,910,000	$ 5,332,000
Aggregate intrinsic value of options exercised				$ 100,000	1,500,000
Unvested restricted stock units		1,472,741		1,472,741		1,759,918
RSUs
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vesting period				4 years
Weighted-average recognition period				1 year 9 months 18 days
Unvested restricted stock units		1,472,741		1,472,741		1,759,918
Fair value RSUs vested		$ 1,800,000	$ 0	$ 3,600,000	$ 0
Number of Restricted stock units, Granted		0		0
Weighted average granted date fair value			$ 11.97		$ 15.1
Expected to be recognized as stock-based compensation expense, RSUs		$ 15,100,000		$ 15,100,000
Maximum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Weighted-average grant date fair value of the stock options granted				$ 8.65	20.5
2022 Equity Incentive Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Increase in common stock reserved for issuance as percentage of outstanding shares of common stock	5.00%
2022 Employee Stock Purchase Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
New shares issued				0
Increase in common stock reserved for issuance as percentage of outstanding shares of common stock	1.00%
Stock-based compensation expense				$ 0
Stock Options
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Contractual term of stock option award				10 years
Weighted-average grant date fair value of the stock options granted		$ 4.91	$ 8.92	$ 4.1	$ 10.49
Unrecognized stock-based compensation expense		$ 13,500,000		$ 13,500,000
Weighted-average recognition period				2 years 7 months 6 days
Total fair value of options vested		$ 1,000,000	$ 500,000	$ 2,000,000	$ 800,000
Stock Options \| Maximum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vesting period				4 years

Investments

6 Months Ended

Jun. 30, 2024

Investments, Debt and Equity Securities [Abstract]

Investments

3. Investments


	June 30, 2024
Short-term investments:	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Fair Value
U.S. Treasury securities	$	134,588	$	3	$	(60	)	$	134,531
Long-term investments:
U.S. Treasury securities		39,857		38		—			39,895
	$	174,445	$	41	$	(60	)	$	174,426


	December 31, 2023
	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Fair Value
Short-term investments:
U.S. Treasury securities	$	41,470	$	22	$	(19	)	$	41,473
U.S. government-sponsored enterprise securities		50,056		—		(86	)		49,970
	$	91,526	$	22	$	(105	)	$	91,443

Certain short-term debt securities with original maturities of less than 90 days are included in cash and cash equivalents on the condensed consolidated balance sheets and are not included in the tables above. As of June 30, 2024 and December 31, 2023, all short-term investments had contractual maturities within one year. As of June 30, 2024, all long-term investments had contractual maturities between one to two years.

The aggregate fair value of available-for-sale securities held by the Company in an unrealized loss position for less than 12 months as of June 30, 2024 was $119.9 million. There were no available-for-sale securities in a continuous unrealized loss position for greater than 12 months. The Company evaluated its securities for potential impairment and considered the decline in market value to be primarily attributable to current economic and market conditions. Additionally, the Company does not intend to sell the investments in an unrealized loss position and does not expect it will be required to sell the investments before recovery of their amortized cost bases, which may be maturity. Given the Company's intent and ability to hold such investments until recovery, and the lack of a significant change in credit risk for these investments, the Company does not consider these investments to be impaired and there are no allowances for credit losses as of June 30, 2024.

Insider Trading Arrangements

3 Months Ended

Jun. 30, 2024

Trading Arrangements, by Individual

Material Terms of Trading Arrangement

Rule 10b5-1 Trading Plans

The adoption or termination of contracts, instructions or written plans for the potential purchase or sale of our securities by our Section 16 officers and directors for the three months ended June 30, 2024, each of which is intended to satisfy the affirmative defense of Rule 10b5-1(c) ("Rule 10b5-1 Plan"), were as follows:


Name	Title	Action	Date Adopted	Expiration Date	Maximum Number of Securities to Be Sold
Peter Blume-Jensen	CEO, President, Chairman of the board	Adoption	05/28/2024	09/20/2025	440,000
Kristina Masson	EVP Business Operations, Director	Adoption	05/28/2024	09/20/2025	120,000
Eric Devroe	Chief Operating Officer	Adoption	05/29/2024	09/20/2025	20,275
Jean-Marie Cuillerot	Chief Medical Officer	Adoption	06/12/2024	09/20/2025	4,800
Katharine Peterson	Chief Accounting Officer	Adoption	06/13/2024	09/20/2025	19,000
Mary-Alice Miller	Chief Legal Officer	Adoption	06/14/2024	09/20/2025	10,582
Erick Gamelin	Chief Development Officer	Adoption	06/18/2024	09/20/2025	32,600

The above potential sales are contingent on the market price of the Company’s common stock being higher than certain minimum threshold prices specified in each 10b5-1 Plan.

Other than as described above, to date June 30, 2024, none of our directors or Section 16 reporting officers adopted or terminated any Rule 10b5-1 trading arrangement or non-Rule 10b5-1 trading arrangement (as such terms are defined in Item 408 of the SEC's Regulation S-K).

Rule 10b5-1 Arrangement Adopted

false

Non-Rule 10b5-1 Arrangement Adopted

false

Rule 10b5-1 Arrangement Terminated

false

Non-Rule 10b5-1 Arrangement Terminated

false

Peter Blume-Jensen

Trading Arrangements, by Individual

Name

Peter Blume-Jensen

Title

CEO, President, Chairman of the board

Rule 10b5-1 Arrangement Adopted

true

Non-Rule 10b5-1 Arrangement Adopted

false

05/28/2024

09/20/2025

481 days

440,000

Trading Arrangements, by Individual

Name

Kristina Masson

Title

EVP Business Operations, Director

Rule 10b5-1 Arrangement Adopted

true

Non-Rule 10b5-1 Arrangement Adopted

false

05/28/2024

09/20/2025

481 days

120,000

Trading Arrangements, by Individual

Name

Eric Devroe

Title

Chief Operating Officer

Rule 10b5-1 Arrangement Adopted

true

Non-Rule 10b5-1 Arrangement Adopted

false

05/29/2024

09/20/2025

480 days

20,275

Trading Arrangements, by Individual

Name

Jean-Marie Cuillerot

Title

Chief Medical Officer

Rule 10b5-1 Arrangement Adopted

true

Non-Rule 10b5-1 Arrangement Adopted

false

06/12/2024

09/20/2025

466 days

4,800

Trading Arrangements, by Individual

Name

Katharine Peterson

Title

Chief Accounting Officer

Rule 10b5-1 Arrangement Adopted

true

Non-Rule 10b5-1 Arrangement Adopted

false

06/13/2024

09/20/2025

465 days

19,000

Trading Arrangements, by Individual

Name

Mary-Alice Miller

Title

Chief Legal Officer

Rule 10b5-1 Arrangement Adopted

true

Non-Rule 10b5-1 Arrangement Adopted

false

06/14/2024

09/20/2025

464 days

10,582

Trading Arrangements, by Individual

Name

Erick Gamelin

Title

Chief Development Officer

Rule 10b5-1 Arrangement Adopted

true

Non-Rule 10b5-1 Arrangement Adopted

false

06/18/2024

09/20/2025

460 days

32,600

Employee Benefit Plans

6 Months Ended

Jun. 30, 2024

Retirement Benefits [Abstract]

Employee Benefit Plans

12. Employee Benefit Plans

Effective January 1, 2019, the Company adopted a 401(k) Plan for its employees, which is designed to be qualified under Section 401(k) of the Internal Revenue Code. Eligible employees are permitted to contribute to the 401(k) Plan within statutory and 401(k) Plan limits. Since inception of the 401(k) Plan and through the six months ended June 30, 2024, the Company has not made any contributions to the 401(k) Plan.

- Definition

The entire disclosure for retirement benefits.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 715
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-Section 50
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-URI https://asc.fasb.org/1943274/2147480794/715-70-50-1

Reference 2: http://www.xbrl.org/2003/role/exampleRef
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Reference 3: http://www.xbrl.org/2003/role/disclosureRef
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Reference 4: http://www.xbrl.org/2003/role/disclosureRef
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Reference 5: http://www.xbrl.org/2003/role/disclosureRef
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Reference 6: http://www.xbrl.org/2003/role/disclosureRef
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Reference 7: http://www.xbrl.org/2003/role/disclosureRef
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-URI https://asc.fasb.org/715/tableOfContent

Reference 8: http://www.xbrl.org/2003/role/disclosureRef
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Reference 9: http://www.xbrl.org/2003/role/disclosureRef
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Reference 10: http://www.xbrl.org/2003/role/disclosureRef
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Reference 13: http://www.xbrl.org/2003/role/disclosureRef
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-URI https://asc.fasb.org/1943274/2147480126/715-20-S99-2

Reference 14: http://www.xbrl.org/2003/role/disclosureRef
-Topic 715
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-Section 50
-Paragraph 3
-Subparagraph (c)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480266/715-60-50-3

+ Details

Stockholders' Equity - Additional Information (Details) - USD ($) $ / shares in Units, $ in Millions	Apr. 11, 2024	Apr. 08, 2024	Jun. 30, 2024	Dec. 31, 2023	Oct. 31, 2022
Class of Stock [Line Items]
Preferred stock, authorized			10,000,000	10,000,000
Preferred stock, par value			$ 0.001	$ 0.001
Preferred stock, shares, issued			0	0
Preferred stock, shares, outstanding			0	0
Common stock, shares authorized			500,000,000	500,000,000
Common stock, per share value			$ 0.001	$ 0.001
Pre-Funded Warrants exercised			0
Pre-Funded Warrants
Class of Stock [Line Items]
Pre-Funded Warrant Notice Period		61 days
Pre-Funded Warrants \| Common Stock \| Minimum
Class of Stock [Line Items]
Shares outstanding percentage		4.99%
Pre-Funded Warrants \| Common Stock \| Maximum
Class of Stock [Line Items]
Shares outstanding percentage		19.99%
PIPE Securities Purchase Agreement
Class of Stock [Line Items]
Common Stock Shares Issued		8,235,000
Common stock price per share		$ 8.5
Issuance costs	$ 6.2
PIPE Securities Purchase Agreement \| Pre-Funded Warrants
Class of Stock [Line Items]
Shares of common stock issuable upon exercise of warrants		7,060,000
Purchase price per Warrant		$ 8.499
Exercise Price per Share		$ 0.001
PIPE Securities Purchase Agreement \| Pre-Funded Warrants \| Maximum
Class of Stock [Line Items]
Shares of common stock issuable upon exercise of warrants		7,060,000
Initial Public Offering
Class of Stock [Line Items]
Preferred stock, authorized					10,000,000
Preferred stock, par value					$ 0.001
April 2024 Private Placement
Class of Stock [Line Items]
Net proceeds from issuance of private placement	$ 123.8

Stock-Based Compensation - Assumptions of Grant Date Fair Value of Stock Options Granted (Details) - $ / shares	6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Risk-free interest rate range, minimum	3.93%	3.40%
Risk-free interest rate range, maximum	4.57%	4.28%
Dividend yield	0.00%	0.00%
Volatility rate range, minimum	81.06%	82.62%
Volatility rate range, maximum	82.31%	83.55%
Minimum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Expected life of options (years)	5 years 6 months	5 years 9 months 18 days
Fair value of common stock range	$ 3.54	$ 11.95
Maximum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Expected life of options (years)	6 years 1 month 6 days	6 years 1 month 6 days
Fair value of common stock range	$ 8.65	$ 20.5

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (UNAUDITED) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023
Cash flows from operating activities:
Net loss			$ (35,284)	$ (26,670)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation expense	$ 200	$ 100	452	254
Stock-based compensation expense			6,910	5,332
Non-cash lease expense			453	386
Net amortization of premiums and accretion of discounts on investments			(1,676)	(1,901)
Changes in operating assets and liabilities:
Prepaid expenses and other current assets			413	2,016
Accounts payable			(3,215)	363
Accrued expenses and other liabilities			1,384	111
Operating lease liabilities			(423)	(360)
Net cash used in operating activities			(30,986)	(20,469)
Cash flows from investing activities:
Purchases of short-term and long-term investments			(163,167)	(16,963)
Proceeds from maturities of short-term investments			81,925	45,765
Purchases of property and equipment			(952)	(137)
Net cash (used in) provided by investing activities			(82,194)	28,665
Cash flows from financing activities:
Proceeds from issuance of common stock in private placement			69,997
Proceeds from issuance of pre-funded warrants in private placement			60,003
Proceeds from exercise of stock options			90	379
Payments of offering costs			(6,236)
Payments of tax withholdings related to vesting of restricted stock units			(676)
Net cash provided by financing activities			123,178	379
Net increase in cash, cash equivalents, and restricted cash			9,998	8,575
Cash, cash equivalents and restricted cash at beginning of period			36,429	29,907
Cash, cash equivalents and restricted cash at end of period	46,427	38,482	46,427	38,482
Supplemental disclosure of non-cash investing and financing activities:
Purchases of property and equipment included in accounts payable			123
Offering costs in accounts payable and accrued expenses and other current liabilities			308
Reconciliation of cash, cash equivalents, and restricted cash:
Cash and cash equivalents	46,006	38,074	46,006	38,074
Restricted cash	421	408	421	408
Total cash, cash equivalents, and restricted cash	$ 46,427	$ 38,482	$ 46,427	$ 38,482

Nature of the Business - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands				3 Months Ended				6 Months Ended
	Apr. 11, 2024	Apr. 08, 2024	Dec. 15, 2023	Jun. 30, 2024	Mar. 31, 2024	Jun. 30, 2023	Mar. 31, 2023	Jun. 30, 2024	Jun. 30, 2023	Dec. 31, 2023
Organization Consolidation Presentation Of Financial Statements [Line Items]
Net loss				$ 18,798	$ 16,486	$ 13,914	$ 12,756	$ 35,284	$ 26,670
Accumulated deficit				151,704				151,704		$ 116,420
Aggregate net proceeds private placement								69,997
Cash, cash equivalents and investments				$ 220,400				$ 220,400
PIPE Securities Purchase Agreement
Organization Consolidation Presentation Of Financial Statements [Line Items]
Common Stock Shares Issued		8,235,000
Common stock price per share		$ 8.5
Issuance costs	$ 6,200
PIPE Securities Purchase Agreement \| Pre-Funded Warrants
Organization Consolidation Presentation Of Financial Statements [Line Items]
Shares of common stock issuable upon exercise of warrants		7,060,000
Purchase price per Warrant		$ 8.499
Exercise Price per Share		$ 0.001
PIPE Securities Purchase Agreement \| Maximum \| Pre-Funded Warrants
Organization Consolidation Presentation Of Financial Statements [Line Items]
Shares of common stock issuable upon exercise of warrants		7,060,000
ATM Program \| Maximum
Organization Consolidation Presentation Of Financial Statements [Line Items]
Aggregate offering price			$ 300,000
ATM Program \| Sale Agreement \| Maximum
Organization Consolidation Presentation Of Financial Statements [Line Items]
Issuance and sale of common stock			$ 100,000
April 2024 Private Placement
Organization Consolidation Presentation Of Financial Statements [Line Items]
Net proceeds from issuance of private placement	$ 123,800

Commitments and Contingencies

6 Months Ended

Jun. 30, 2024

Commitments and Contingencies Disclosure [Abstract]

Commitments and Contingencies

11. Commitments and Contingencies

Leases

The Company’s commitments under its operating leases are described in Note 7.

License Agreement

In January 2021, the Company entered into a license agreement and stock issuance agreement with Eli Lilly and Company (“Lilly”) (collectively, the “Lilly Agreement”), pursuant to which the Company has been granted an exclusive, royalty-bearing sublicensable license to certain patents owned or controlled by Lilly, with world-wide rights to commercially develop, manufacture, use, distribute and sell therapeutic products containing the compound prexasertib. The license from Lilly comprises three families of patent filings all relating to ACR-368. Additionally, pursuant to the Lilly Agreement, the Company received ACR-368 drug substance and drug product to be used in future research.

As initial consideration for the license, the Company made a one-time, non-creditable, non-refundable upfront payment of $5.0 million. As additional consideration for the license, the Company is required to pay Lilly aggregate development and commercial milestone payments of up to $168.0 million, of which $5.0 million is due prior to a new drug application.

The Company is also obligated to pay a tiered percentage royalty on annual net sales ranging from single-digit up to a maximum of 10%, subject to certain specified reductions. Royalties are payable by the Company on a licensed product-by-licensed product and country-by-country basis until the later of the expiration of the last valid claim covering the licensed product in such country, expiration of all applicable regulatory exclusivities in such country for such licensed product and the tenth anniversary of the first commercial sale of such licensed product in such country, provided, that the Company’s obligation to pay royalties for a given licensed product in a given country will expire earlier upon achievement of certain sales thresholds by generic products in such country.

As of June 30, 2024, no milestone payments or royalties have been incurred related to the Lilly Agreement.

Companion Diagnostic Agreement

In June 2022, the Company entered into a companion diagnostic agreement (the “Akoya Agreement”) with Akoya Biosciences, Inc. (“Akoya”), pursuant to which the Company has engaged Akoya to co-develop, validate, and commercialize the Company’s proprietary ACR-368 OncoSignature test, the companion diagnostic that will be used to identify patients with cancer most likely to respond to ACR-368. Subject to the terms of the Akoya Agreement, as subsequently amended, the Company paid Akoya a one-time, non-refundable, non-creditable upfront payment in the amount of $0.6 million. The Company is obligated to pay Akoya up to an aggregate of $17.3 million upon the achievement of specified development milestones. Through June 30, 2024, the Company has made aggregate payments of $10.1 million to Akoya. During the three months ended June 30, 2024, the Company recorded $1.8 million of research and development expense related to the achievement of milestones. No milestones were achieved during the three months ended June 30, 2023. During the six months ended June 30, 2024 and 2023, the Company recorded $1.8 million and $1.5 million, respectively, of research and development expense related to the achievement of milestones.

Indemnification Agreements

In the ordinary course of business, the Company may provide indemnification of varying scope and terms to vendors, lessors, business partners and other parties with respect to certain matters including, but not limited to, losses arising out of breach of such

agreements or from intellectual property infringement claims made by third parties. In addition, the Company has entered into indemnification agreements with each of its directors and executive officers that will require the Company, among other things, to indemnify them against certain liabilities that may arise by reason of their status or services as directors or executive officers. The maximum potential amount of future payments the Company could be required to make under these indemnification agreements is, in many cases, unlimited. To date, the Company has not incurred any material costs as a result of such indemnifications. The Company is not currently aware of any indemnification claims and has not accrued any liabilities related to such obligations in its financial statements as of June 30, 2024 and December 31, 2023.

Legal Proceedings

From time to time, in the ordinary course of business, the Company is subject to litigation and regulatory examinations as well as information gathering requests, inquiries and investigations. The Company is not currently party to any material legal proceedings and is not aware of any pending or threatened legal proceedings that could have an adverse effect on the Company's business, operating results or financial condition.

Other Contracts

The Company enters into contracts in the normal course of business with various third parties for preclinical research studies, clinical trials, testing, manufacturing and other services. These contracts generally provide for termination upon notice and are cancelable without significant penalty or payment, and do not contain any minimum purchase commitments.

Property and Equipment, Net - Additional Information (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023
Property, Plant and Equipment [Abstract]
Depreciation expense	$ 200	$ 100	$ 452	$ 254

Fair Value Measurements - Additional Information (Detail) - USD ($)	6 Months Ended	12 Months Ended
	Jun. 30, 2024	Dec. 31, 2023
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Fair value measurement with unobservable inputs reconciliation liability transfers between levels	$ 0	$ 0
Preferred stock, shares, issued	0	0

Net Loss Per Share - Summary of Potentially Dilutive Securities (Details) - shares	6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023
Options to purchase common stock
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of diluted net loss per share	4,356,771	3,130,630
Unvested restricted stock units
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of diluted net loss per share	1,472,741	1,805,055

Investments - Additional Information (Details) - USD ($)	6 Months Ended	12 Months Ended
	Jun. 30, 2024	Dec. 31, 2023
Debt Securities, Available-for-Sale [Line Items]
Investments, contractual maturities short-term investments	1 year	1 year
Unrealized loss position greater than 12 months	$ 0
Unrealized loss position less than 12 months	119,900,000
Allowance for credit losses	$ 0
Minimum
Debt Securities, Available-for-Sale [Line Items]
Investments, contractual maturities long-term investments	1 year
Maximum
Debt Securities, Available-for-Sale [Line Items]
Investments, contractual maturities long-term investments	2 years

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481800/320-10-50-2

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
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-Paragraph 2
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481800/320-10-50-2

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Topic 320
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-Section 50
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-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481800/320-10-50-2

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
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Reference 5: http://www.xbrl.org/2003/role/disclosureRef
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-Paragraph 2
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481800/320-10-50-2

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
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-URI https://asc.fasb.org/1943274/2147481800/320-10-50-2

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
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Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Topic 320
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-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481800/320-10-50-3

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Topic 320
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-Name Accounting Standards Codification
-Section 50
-Paragraph 3
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481800/320-10-50-3

Reference 10: http://www.xbrl.org/2003/role/disclosureRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 3
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481800/320-10-50-3

Reference 11: http://www.xbrl.org/2003/role/disclosureRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
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-URI https://asc.fasb.org/1943274/2147481800/320-10-50-3

Reference 12: http://www.xbrl.org/2003/role/disclosureRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 3
-Subparagraph (d)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481800/320-10-50-3

+ Details

Stockholders' Equity - Schedule of Common Stock Shares Reserved for the Potential Conversion of Outstanding Preferred Stock and Exercise of Stock Options (Details) - shares	Jun. 30, 2024	Dec. 31, 2023
Class of Stock Disclosures [Abstract]
Options to purchase common stock	4,356,771	3,117,042
Pre-funded warrants to purchase common stock	7,060,000
Unvested restricted stock units	1,472,741	1,759,918
Remaining shares reserved for future issuance	2,297,940	2,107,745
Total	15,187,452	6,984,705